Two jobs isn't really a positive - game dev can be taxing in terms of time and effort, so the main concern would be an employee that works a second job would be more exhausted and less able to complete her tasks. If that candidate can persuade the hiring manager that she'll be able to do the job we're hiring for and that her other job isn't directly competing with us (e.g. working for another game studio at the same time), then everything should be fine. If you've got a side hustle in an unrelated field (e.g. selling plushes on Etsy), it won't be held against you.
Any hiring manager will reasonably expect a candidate to quit her job at another game studio to come work for us if she accepts an employment offer. It's a pretty standard "No Moonlighting" clause in the employment contract.
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